Audit: QRS - Ayahuasca for Health & Longevity
Audit conducted on 30/06/2026 17:33 using AI4L / Opus 4.8
Summary
| Items | Count |
|---|---|
| Total | 91 |
| Passed | 91 |
| Failed | 0 |
| N/A | 0 |
| Pass Rate | 100.00% |
- Total = Passed + Failed + N/A
- Pass Rate = Passed / (Passed + Failed) × 100
- N/A items are excluded from the pass rate calculation
Note: The QRS.md prompt declares [total_items] = 71, but the checklist as written enumerates 91 distinct items (sections 1–15). The audit was performed against the actual 91 enumerated items.
1. General Rules
| # | Description | Result | Comments |
|---|---|---|---|
| 1.1 | Every claim, magnitude, label, recommendation, and statement in the QRS is literally supported by content in the source ER. | 🟢 | All QRS content (at-a-glance, protocol, time-to-effect, benefits, risks, contraindications, interactions, monitoring, qualitative) traces to ER passages. |
| 1.2 | Where the ER uses cautious phrasing (“not formally studied”, “None documented in human trials to date”, “theoretical concern”, “data are limited”), the QRS uses the same phrasing. | 🟢 | Cautious framing preserved (e.g., “durability beyond uncertain”, “Speculative” tier matches ER Speculative sections). |
| 1.3 | The QRS never strengthens an ER claim (e.g., “not formally studied” → “not required”) or softens one (e.g., “do not use during pregnancy” → “use with caution during pregnancy”). | 🟢 | No strengthening/softening; pregnancy and serotonergic-med items kept as contraindications. |
| 1.4 | The QRS does not relabel an ER fact under a different decision category. A “Benefit-Modifying Factor” from ER section is not surfaced as a “Caution”; a “Risk-Modifying Factor” is not surfaced as a “Side Effect”; etc. | 🟢 | Contraindications/interactions drawn from ER Key Interactions & Contraindications; risks from Potential Risks; categories preserved. |
| 1.5 | PubMed IDs, study citations, expert names, clinical trial identifiers (NCT*), and brand names appear in the QRS only if they appear in the source ER for the same fact. | 🟢 | No PMIDs, NCT IDs, expert names, or brand names introduced in the QRS. |
| 1.6 | The QRS does not introduce new attributions. | 🟢 | No new attributions present. |
2. Focus, Tone & Audience
| # | Description | Result | Comments |
|---|---|---|---|
| 2.1 | The QRS follows the tone of the ER, which is determined by the ER’s own language, phrasing, and framing. | 🟢 | Cautious, evidence-graded tone matches ER. |
| 2.2 | The tone of the QRS is simultaneously expert, accessible, objective, and data-driven, but also empowering and encouraging | 🟢 | Expert yet accessible framing maintained. |
| 2.3 | The QRS reads as a trusted, knowledgeable guide rather than a prescriptive doctor | 🟢 | Presents evidence without prescribing. |
| 2.4 | The QRS avoids language that implies medical or clinical advice | 🟢 | Descriptive of research/clinical practice, not advice to reader. |
| 2.5 | The QRS “presents information” instead of “providing guidance”, “recommending”, or “advising” | 🟢 | Informational framing throughout. |
| 2.6 | The QRS never addresses “the reader” directly — it presents evidence, not guidance | 🟢 | No second-person address; cadence verbs mirror ER’s descriptive protocol language. |
| 2.7 | The QRS is written in plain language, avoiding unnecessary medical jargon | 🟢 | Technical terms expanded or avoided where appropriate. |
| 2.8 | Information is presented in a concise and very compact manner | 🟢 | Cells and bullets are compact. |
| 2.9 | It DOES NOT address the reader directly | 🟢 | No direct reader address. |
| 2.10 | The target audience is health- and longevity-oriented adults who are risk-aware, proactive, and actively seeking to optimize health or apply the intervention under review. | 🟢 | Framing fits proactive, risk-aware audience. |
| 2.11 | The target audience is willing to employ lifestyle and behavioral changes as well as follow protocols that may be inconvenient, costly, or require effort. | 🟢 | Protocol detail (washout, screening, supervision) consistent with this audience. |
| 2.12 | The document is NOT written for the general population, who are unwilling to employ lifestyle and behavioral changes or follow protocols that may be inconvenient, costly, or require effort. | 🟢 | Not pitched to general population. |
| 2.13 | Framing, takeaways, and risk/benefit weighting throughout the document reflect this audience, including where an intervention’s signal for the average person differs from its signal for this audience. | 🟢 | Risk/benefit weighting reflects target audience. |
| 2.14 | The document’s own voice frames usage in longevity terms, not “anti-aging”. Proper names that contain “anti-aging” are quoted verbatim. | 🟢 | No “anti-aging” usage. |
| 2.15 | The document’s own voice uses formal clinical and scientific terminology, not colloquial or consumer-grade language. Direct quotes from sources are exempt. | 🟢 | “Bad trips” is the ER’s own risk title (verbatim); otherwise formal register used. |
3. Template Integrity
| # | Description | Result | Comments |
|---|---|---|---|
| 3.1 | The following labels and headings on the QRS are fixed and not modified: Card and section headings (“Protocol”, “Time to effect”, “Benefits”, “Risk & Side Effects”, “Monitoring”, “Qualitative Assessment”); Gate headings (“Contraindications”, “Key Interactions”); Tier labels (“High”, “Medium”, “Low”, “Speculative”); Table column headers in Monitoring (“Marker”, “Target”, “Why”). | 🟢 | All fixed headings/labels present and unmodified. |
| 3.2 | All “…” from the [qrs_template] are present in the QRS. | 🟢 | All expected data-qrs-var spans present, including hidden benefits_high. |
| 3.3 | Spans that are not addressed in a checklist item are left unchanged | 🟢 | No unaddressed spans altered. |
4. Formatting
| # | Description | Result | Comments |
|---|---|---|---|
| 4.1 | When the source ER section is empty, the QRS uses the ER’s own empty-state phrasing verbatim. Typical phrasings are “None documented in human trials to date” and “Not formally studied” | 🟢 | benefits_high (empty High tier) set to display:none rather than filled, consistent with empty-state handling. |
| 4.2 | Where the ER presents a bulleted item as “Label: content”, the QRS uses the ER’s bold label verbatim as the cell or row label. | 🟢 | Protocol/monitoring labels derive from ER content. |
| 4.3 | Labels are not paraphrased, abbreviated, or invented. | 🟢 | Labels faithful to ER. |
| 4.4 | The QRS DOES NOT use emoji indicators (no 🟩, 🟥, 🟨, etc.). Color and emphasis are conveyed through CSS and bold labels. | 🟢 | No emoji indicators in QRS body. |
| 4.5 | The QRS is designed to render on one A4 page. Any section that has more content in the ER than fits the per-section budget is condensed by the LLM, not extended onto a second page. | 🟢 | Content condensed to single-page budget. |
5. Metadata
| # | Description | Result | Comments |
|---|---|---|---|
| 5.1 | The metadata is placed inside a single HTML comment that is the first element after “<!doctype html>” and before any other comment, head, or body content. | 🟢 | Metadata comment is first element after doctype. |
| 5.2 | Inside that HTML comment the YAML block is delimited by a line “—” opening and a line “—” closing. | 🟢 | YAML delimited correctly. |
| 5.3 | The metadata is not visible in any rendered view of the QRS and is not surfaced by any other element on the sheet. | 🟢 | Inside HTML comment; not rendered. |
| 5.4 | All frontmatter values are trimmed: no leading or trailing whitespace, no surrounding quotes unless required by YAML. | 🟢 | Values trimmed; duration quoted appropriately (contains colon). |
| 5.5 | The filename of the source ER is stated as “er_filename: [er_filename]” | 🟢 | er_filename: ayahuasca_2026-0630-1528_Opus_ER.md. |
| 5.6 | Version of the QRS.md file used to create the document is stated as “qrs_prompt_version: [Version of QRS.md]” | 🟢 | qrs_prompt_version: 26.5.18 matches QRS.md. |
| 5.7 | Creation date and time is stated as “qrs_creation_date: [YYYY-MMDD-HHMM]” | 🟢 | qrs_creation_date: 2026-0630-1528. |
| 5.8 | The nickname of the AI is stated as “qrs_creator_ai_nickname: [qrs_creator_ai_nickname]” | 🟢 | qrs_creator_ai_nickname: Opus. |
| 5.9 | The nickname of the AI is just a single word model name without version, etc. | 🟢 | “Opus” — single word. |
| 5.10 | The full name of the AI is stated as “qrs_creator_ai_fullname: [qrs_creator_ai_fullname]” | 🟢 | qrs_creator_ai_fullname: Opus 4.8. |
| 5.11 | The full name consists of the nickname and the model version number and no additional qualifier | 🟢 | “Opus 4.8” — nickname + version. |
| 5.12 | The filename of the document is stated as “qrs_filename: [filename of this document]” | 🟢 | qrs_filename: ayahuasca_2026-0630-1528_Opus_QRS.html. |
| 5.13 | All frontmatter values are trimmed: no leading or trailing whitespace, no surrounding quotes unless required. | 🟢 | All values clean. |
6. Page Title & Header
| # | Description | Result | Comments |
|---|---|---|---|
| 6.1 | [page_title] is set to the [canonical_topic] of the ER frontmatter followed by “ - Quick Reference Sheet”. The [canonical_topic] is HTML-entity-encoded as needed. | 🟢 | “Ayahuasca for Health & Longevity - Quick Reference Sheet”. |
| 6.2 | [header_topic] is set to the [canonical_topic] of the ER frontmatter, with HTML entities encoded as needed. | 🟢 | “Ayahuasca for Health & Longevity”. |
| 6.3 | [header_subline_date] is set to [qrs_creation_date reformatted as MM/DD/YYYY] | 🟢 | “06/30/2026” from 2026-0630. |
| 6.4 | [header_subline_model] is set to [qrs_creator_ai_fullname] | 🟢 | “Opus 4.8”. |
| 6.5 | No additional header content appears: no badge, version stamp, AKA / alternate names line, source-AI attribution, audit date, or QRS variant marker. | 🟢 | Header limited to title and subline; no extra content. |
7. At-A-Glance Section
| # | Description | Result | Comments |
|---|---|---|---|
| 7.1 | [at_a_glance] is dense, execution-oriented summary of the ER Conclusion section |
🟢 | Distills ER Conclusion (lines 449-453). |
| 7.2 | [at_a_glance] is no longer than 60 words | 🟢 | 56 words. |
| 7.3 | Every fact in [at_a_glance] is supported by a distinct passage in the ER. | 🟢 | Each clause maps to ER Conclusion passages. |
| 7.4 | It DOES NOT use acronyms or technical classifications that require specialist knowledge, uses plain-language terms instead | 🟢 | Plain-language only (“mind-altering compound”, “substances from a vine”); no acronyms. |
| 7.5 | It DOES NOT cite specific trials (names, years, sample sizes, p-values) | 🟢 | No trial citations. |
| 7.6 | It DOES NOT cite effect sizes, relative risks, or statistical results | 🟢 | No statistics. |
8. Contraindications
| # | Description | Result | Comments |
|---|---|---|---|
| 8.1 | The section is derived from the ER Key Interactions & Contraindications section |
🟢 | Derived from ER lines 298-312. |
| 8.2 | [stop_items] represent the Contraindications from the ER | 🟢 | All ER contraindications present (psychosis/bipolar, CVD, pregnancy/breastfeeding, liver disease, serotonergic meds, monoamine-affecting agents). |
| 8.3 | Individual [stop_items] are formatted as <li></li> | 🟢 | Each item is an <li>. |
| 8.4 | Items are as concise as possible. No trailing explanations/elaborations/rationale/attributions/citations/study details. No content after an em/en/hyphen dash. | 🟢 | Items are bare facts; no trailing dash clauses. |
| 8.5 | Parenthetical qualifiers from the ER bullet — time windows, severity classes, threshold values, clinical staging — ARE preserved, kept concise. | 🟢 | “<90 days”, “Child-Pugh Class B or C”, “uncontrolled hypertension, serious arrhythmia” preserved. |
| 8.6 | When the ER uses ranking notation inside parens that depends on an explanatory phrase, normalize to a plain comma-separated list. | 🟢 | No ranking notation; lists are plain comma-separated. |
| 8.7 | If no [stop_items] are present the section is left empty | 🟢 | stop_items present, so condition does not trigger; section correctly populated. |
9. Key Interactions
| # | Description | Result | Comments |
|---|---|---|---|
| 9.1 | The section is derived from the ER Key Interactions & Contraindications section |
🟢 | Derived from ER lines 298-311. |
| 9.2 | [caution_items] represent the Key Interactions from the ER, excluding any already listed as Contraindications | 🟢 | Antidepressants (absolute contraindication/serious caution), tyramine foods, serotonin precursors, additive supplements, alcohol/other drugs listed; contraindication framed distinctly as “without completed washout”. |
| 9.3 | Individual [caution_items] are formatted as <li></li> | 🟢 | Each item is an <li>. |
| 9.4 | Items are as concise as possible. No trailing explanations/rationale/attributions/citations/study details. No content after an em/en/hyphen dash. | 🟢 | Items are concise; no trailing dash clauses. |
| 9.5 | Parenthetical qualifiers from the ER bullet — example drug lists, time windows, severity classes, threshold values, clinical staging — ARE preserved, kept concise. | 🟢 | Example drug lists preserved (SSRIs, SNRIs, MAO inhibitors, tricyclics, St. John’s Wort; 5-HTP, L-tryptophan, SAMe; high-dose yohimbine). |
| 9.6 | When the ER uses ranking notation inside parens, normalize to a plain comma-separated list. | 🟢 | No ranking notation; plain lists used. |
| 9.7 | If no [caution_items] are present the section is left empty | 🟢 | caution_items present; condition does not trigger; section correctly populated. |
10. Protocol
| # | Description | Result | Comments |
|---|---|---|---|
| 10.1 | The section is derived from the ER Protocol section |
🟢 | Derived from ER Therapeutic Protocol (lines 332-356). |
| 10.2 | The three sets of [action] items cover the three most important actionable implementation aspects from the ER Protocol section |
🟢 | Research-clinical dose, best time of day, single vs. split dosing — the key actionable aspects. |
| 10.3 | If less than three distinct actionable implementation aspects are mentioned, the unused sets are left empty and made invisible. | 🟢 | Three aspects present; condition does not trigger. |
| 10.4 | All used [action_#label], [action#value], [action#_sub] items are filled with meaningful content derived from the ER Protocol section. |
🟢 | All three action cells fully populated from ER. |
11. Time to Effect
| # | Description | Result | Comments |
|---|---|---|---|
| 11.1 | The three sets of [time] items cover the three most important time-to-effect aspects from the ER | 🟢 | Mood/well-being onset, acute onset, acute resolution. |
| 11.2 | The sets are picked and ordered by the magnitude of the related benefit | 🟢 | Mood/well-being benefit (Medium tier, highest present) placed first; acute pharmacology timings follow. |
| 11.3 | If less than three distinct time-to-effect aspects are mentioned, the unused sets are left empty and made invisible. | 🟢 | Three aspects present; condition does not trigger. |
| 11.4 | All used [time_#label], [time#value], [time#_sub] items are filled with meaningful content derived from the ER. | 🟢 | All three time cells populated from ER (lines 344, 387). |
| 11.5 | If the ER does not provide any information on time to effect, the section is removed completely from the Protocol Panel |
🟢 | ER provides time-to-effect data; section correctly retained. |
12. Benefits
| # | Description | Result | Comments |
|---|---|---|---|
| 12.1 | The section is derived from the ER Expected Benefits section |
🟢 | Derived from ER Expected Benefits (lines 164-208). |
| 12.2 | Key variables are [benefits_high], [benefits_medium], [benefits_low], [benefits_speculative] | 🟢 | All four variables present. |
| 12.3 | Items are as concise as possible. No explanations/elaborations/effect sizes/qualifiers/attributions/citations/study details/mechanistic explanations. | 🟢 | Benefit items are bare key facts. |
| 12.4 | Parenthetical content — including effect sizes, sample notes, mechanistic hints, and example studies — is stripped, NOT preserved. | 🟢 | No parentheticals in benefit items. |
| 12.5 | If no items of a sub-section are present the respective is set to “display=none”, not filled with empty-state phrasing. | 🟢 | benefits_high (no High benefits in ER) set to display:none. |
13. Risks
| # | Description | Result | Comments |
|---|---|---|---|
| 13.1 | The section is derived from the ER Potential Risks & Side Effects section |
🟢 | Derived from ER Potential Risks & Side Effects (lines 226-280). |
| 13.2 | Key variables are [risks_high], [risks_medium], [risks_low], [risks_speculative] | 🟢 | All four variables present. |
| 13.3 | Items are as concise as possible. No explanations/elaborations/effect sizes/qualifiers/attributions/citations/study details/mechanistic explanations. | 🟢 | Risk items are bare key facts. |
| 13.4 | Parenthetical content — including frequencies, severity grades, sample notes, mechanistic hints, and example studies — is stripped, NOT preserved. | 🟢 | The only parentheticals (“vomiting and diarrhea”, “bad trips”) are the ER’s own risk-title clarifiers, not frequencies/grades/samples/mechanism/studies. |
| 13.5 | If no items of a sub-section are present the respective is set to “display=none”, not filled with empty-state phrasing. | 🟢 | All four tiers populated in ER; condition does not trigger. |
14. Monitoring
| # | Description | Result | Comments |
|---|---|---|---|
| 14.1 | The section is derived from the ER Monitoring section |
🟢 | Derived from ER Monitoring Protocol (lines 409-423). |
| 14.2 | All measurable/quantifiable biomarkers from the Monitoring section are listed |
🟢 | All five ER table markers present (BP, RHR, ALT/AST, CMP, Medication review). |
| 14.3 | [monitoring_cadence] is populated with the monitoring cadence/frequency derived from the ER Monitoring section. It is not left with placeholder text or empty. |
🟢 | Cadence populated from ER line 423. |
15. Qualitative Assessment
| # | Description | Result | Comments |
|---|---|---|---|
| 15.1 | The section is derived from the ER Monitoring section |
🟢 | Derived from ER qualitative markers (lines 425-431). |
| 15.2 | All subjective/qualitative biomarkers from the Monitoring section are listed |
🟢 | All five qualitative markers present (mood, anxiety/rumination, well-being, substance use, tolerability). |
Issues 30/06/2026 17:33
Pass rate 100.00%. No issues found.
Issues 30/06/2026 17:27
- 12.3 / 12.4 — Qualifier not stripped in benefits: benefits_medium (QRS line 525) keeps the parenthetical qualifier “(conflicted)” on the depression item; the tier already encodes evidence strength, so this qualifier is redundant detail that 12.3/12.4 require to be stripped.
Fixes 30/06/2026 17:27
- 12.3 / 12.4 — Qualifier not stripped in benefits: Removed the redundant “(conflicted)” qualifier from benefits_medium so the depression item reads “Reduction of depressive symptoms” with no parenthetical.