Audit: QRS - Calendula officinalis for Health & Longevity of the ER frontmatter

Audit conducted on 09/08/2026 17:59 using AI4L / Grok 4

Iterations

Summary

Items	Count
Total	91
Passed	84
Failed	0
N/A	7
Pass Rate	100.00%

• Total = Passed + Failed + N/A
• Pass Rate = Passed / (Passed + Failed) × 100
• N/A items are excluded from the pass rate calculation

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1. General Rules

#	Description	Result	Comments
1.1	Every claim, magnitude, label, recommendation, and statement in the QRS is literally supported by content in the source ER.	🟢
1.2	Where the ER uses cautious phrasing (“not formally studied”, “None documented in human trials to date”, “theoretical concern”, “data are limited”), the QRS uses the same phrasing.	🟢	Speculative tiers and “(traditional caution)” preserve ER caution; radiation mixed signal kept in at-a-glance.
1.3	The QRS never strengthens an ER claim (e.g., “not formally studied” → “not required”) or softens one (e.g., “do not use during pregnancy” → “use with caution during pregnancy”).	🟢
1.4	The QRS does not relabel an ER fact under a different decision category. A “Benefit-Modifying Factor” from ER section is not surfaced as a “Caution”; a “Risk-Modifying Factor” is not surfaced as a “Side Effect”; etc.	🟢
1.5	PubMed IDs, study citations, expert names, clinical trial identifiers (NCT*), and brand names appear in the QRS only if they appear in the source ER for the same fact.	🟢	None introduced.
1.6	The QRS does not introduce new attributions.	🟢

2. Focus, Tone & Audience

#	Description	Result	Comments
2.1	The QRS follows the tone of the ER, which is determined by the ER’s own language, phrasing, and framing.	🟢
2.2	The tone of the QRS is simultaneously expert, accessible, objective, and data-driven, but also empowering and encouraging	🟢
2.3	The QRS reads as a trusted, knowledgeable guide rather than a prescriptive doctor	🟢
2.4	The QRS avoids language that implies medical or clinical advice	🟢
2.5	The QRS “presents information” instead of “providing guidance”, “recommending”, or “advising”	🟢
2.6	The QRS never addresses “the reader” directly — it presents evidence, not guidance	🟢
2.7	The QRS is written in plain language, avoiding unnecessary medical jargon	🟢	Clinical terms retained where ER decision precision requires them (Asteraceae with common-name list; drug names).
2.8	Information is presented in a concise and very compact manner	🟢
2.9	It DOES NOT address the reader directly	🟢
2.10	The target audience is health- and longevity-oriented adults who are risk-aware, proactive, and actively seeking to optimize health or apply the intervention under review.	🟢
2.11	The target audience is willing to employ lifestyle and behavioral changes as well as follow protocols that may be inconvenient, costly, or require effort.	🟢
2.12	The document is NOT written for the general population, who are unwilling to employ lifestyle and behavioral changes or follow protocols that may be inconvenient, costly, or require effort.	🟢
2.13	Framing, takeaways, and risk/benefit weighting throughout the document reflect this audience, including where an intervention’s signal for the average person differs from its signal for this audience.	🟢	Longevity framing in at-a-glance matches ER conclusion.
2.14	The document’s own voice frames usage in longevity terms, not “anti-aging” (e.g., “anti-aging clinics”, “anti-aging community”, “anti-aging medicine”). Proper names that contain “anti-aging” (e.g., “American Academy of Anti-Aging Medicine”) are quoted verbatim.	🟢
2.15	The document’s own voice uses formal clinical and scientific terminology, not colloquial or consumer-grade language (e.g., “oral medication” not “pill(s)”; “injection” not “shot”; “adverse event” not “bad reaction”). Direct quotes from sources are exempt.	🟢

3. Template Integrity

#	Description	Result	Comments
3.1	The following labels and headings on the QRS are fixed and not modified: Card and section headings: “Protocol”, “Time to effect”, “Benefits”, “Risk & Side Effects”, “Monitoring”, “Qualitative Assessment”; Gate headings: “Contraindications”, “Key Interactions”; Tier labels: “High”, “Medium”, “Low”, “Speculative”; Table column headers in Monitoring: “Marker”, “Target”, “Why”	🟢
3.2	All “…” from the [qrs_template] are present in the the QRS.	🟢	All template variables present; marker_# / qualitative_item_# expanded to numbered spans.
3.3	Spans that are not addressed in a checklist item are left unchanged	🟢

4. Formatting

#	Description	Result	Comments
4.1	When the source ER section is empty, the QRS uses the ER’s own empty-state phrasing verbatim. Typical phrasings are “None documented in human trials to date” and “Not formally studied”	🟢	Empty High benefits tier has no ER empty-state phrase; handled via 12.5 display:none.
4.2	Where the ER presents a bulleted item as “Label: content”, the QRS uses the ER’s bold label verbatim as the cell or row label.	🟢
4.3	Labels are not paraphrased, abbreviated, or invented.	🟢
4.4	The QRS DOES NOT use emoji indicators (no 🟩, 🟥, 🟨, etc.). Color and emphasis are conveyed through CSS and bold labels.	🟢
4.5	The QRS is designed to render on one A4 page. Any section that has more content in the ER than fits the per-section budget is condensed by the LLM, not extended onto a second page.	🟢

5. Metadata

#	Description	Result	Comments
5.1	The metadata is placed inside a single HTML comment that is the first element after “<!doctype html>” and before any other comment, head, or body content.	🟢
5.2	Inside that HTML comment the YAML block is delimited by a line “—” opening and a line “—” closing. Text before the opening “—” is permitted but is not parsed as YAML.	🟢
5.3	The metadata is not visible in any rendered view of the QRS and is not surfaced by any other element on the sheet.	🟢
5.4	All frontmatter values are trimmed: no leading or trailing whitespace, no surrounding quotes unless the value contains a colon, bracket, or leading special character that requires YAML quoting.	🟢	duration quoted (contains colon).
5.5	The filename of the source ER is stated as “er_filename: [er_filename]”	🟢	calendula_officinalis_2026-0809-1520_Grok_ER.md
5.6	Version of the QRS.md file used to create the document is stated as “qrs_prompt_version: [Version of QRS.md]”	🟢	26.7.02
5.7	Creation date and time of the document is stated as “qrs_creation_date: [YYYY-MMDD-HHMM]” (e.g., 2026-0501-1430)	🟢	2026-0809-1707
5.8	The nickname of the AI used to create the document is stated as “qrs_creator_ai_nickname: [qrs_creator_ai_nickname]”	🟢	Grok
5.9	The nickname of the AI is just a single word model name without version, etc. (e.g., Opus, Sonnet, Grok, Gemini, ChatGPT)	🟢
5.10	The full name of the AI used to create the document is stated as “qrs_creator_ai_fullname: [qrs_creator_ai_fullname]”	🟢	Grok 4
5.11	The full name of the AI consists of the [qrs_creator_ai_nickname] and the model version number and no additional qualifier (e.g., Opus 4.6, Sonnet 3.2, Grok 4.5, Gemini 3.1, ChatGPT 5.4)	🟢
5.12	The filename of the document is stated as “qrs_filename: [filename of this document]”	🟢	calendula_officinalis_2026-0809-1520_Grok_QRS.html
5.13	All frontmatter values are trimmed: no leading or trailing whitespace, no surrounding quotes unless the value contains a colon, bracket, or leading special character that requires YAML quoting.	🟢

6. Page Title & Header

#	Description	Result	Comments
6.1	[page_title] is set to the [canonical_topic] of the ER frontmatter followed by “ - Quick Reference Sheet” (e.g., “Intervention - Quick Reference Sheet”). The [canonical_topic] is HTML-entity-encoded as needed (e.g., & for &)	🟢	Calendula officinalis for Health & Longevity - Quick Reference Sheet
6.2	[header_topic] is set to the [canonical_topic] of the ER frontmatter, with HTML entities encoded as needed (e.g., & for &)	🟢
6.3	[header_subline_date] is set to [qrs_creation_date reformatted as MM/DD/YYYY]	🟢	08/09/2026 from 2026-0809-1707
6.4	[header_subline_model] is set to [qrs_creator_ai_fullname]	🟢	Grok 4
6.5	No additional header content appears: no badge, version stamp, AKA / alternate names line, source-AI attribution, audit date, or QRS variant marker.	🟢

7. At-A-Glance Section

#	Description	Result	Comments
7.1	[at_a_glance] is dense, execution-oriented summary of the ER Conclusion section	🟢
7.2	[at_a_glance] is no longer than 60 words	🟢	50 words
7.3	Every fact in [at_a_glance] is supported by a distinct passage in the ER.	🟢
7.4	It DOES NOT use acronyms or technical classifications that require specialist knowledge, uses plain-language terms instead	🟢	daisy-family, birth-related surgical cuts, whole-body
7.5	It DOES NOT cite specific trials (names, years, sample sizes, p-values)	🟢
7.6	It DOES NOT cite effect sizes, relative risks, or statistical results	🟢

8. Contraindications

#	Description	Result	Comments
8.1	The section is derived from the ER Key Interactions & Contraindications section	🟢
8.2	[stop_items] represent the Contraindications from the ER	🟢	Absolute Asteraceae allergy plus populations who should avoid/restrict
8.3	Individual [stop_items] are formatted as <li></li>	🟢
8.4	Items are as concise as possible. No trailing explanations, no elaborations, no mechanistic rationale, no attributions, no citations, no study details. No content after an em-dash, en-dash, or hyphen-dash (e.g., “— dose reduction required”, “— reduced efficacy”) — these trailing clauses are stripped. Just the key fact.	🟢	Trailing “—follow labeled product limits” correctly stripped
8.5	Parenthetical qualifiers from the ER bullet — time windows, severity classes, threshold values, clinical staging — ARE preserved as part of the item, kept as concise as possible (shortened or trimmed where needed to fit the one-page budget, but never dropped entirely).	🟢	absolute/all routes; traditional caution; partial-/full-thickness; age thresholds
8.6	When the ER uses ranking notation inside parens (e.g., “>” for severity ordering) that depends on an explanatory phrase to interpret, normalize the items to a plain comma-separated list rather than carrying through the bare symbol.	N/A	ER stop-related bullets do not use ranking notation
8.7	If no [stop_items] are present the section is left empty	N/A	stop_items are present

9. Key Interactions

#	Description	Result	Comments
9.1	The section is derived from the ER Key Interactions & Contraindications section	🟢
9.2	[caution_items] represent the Key Interactions from the ER, excluding any that are already listed as Contraindications	🟢	Caution/monitor interactions listed; absolute contra and avoid/restrict populations in stop; compatible co-use agents not framed as cautions
9.3	Individual [caution_items] are formatted as <li></li>	🟢
9.4	Items are as concise as possible. No trailing explanations, no elaborations, no mechanistic rationale, no attributions, no citations, no study details. No content after an em-dash, en-dash, or hyphen-dash (e.g., “— dose reduction required”, “— reduced efficacy”) — these trailing clauses are stripped. Just the key fact.	🟢
9.5	Parenthetical qualifiers from the ER bullet — example drug lists, time windows, severity classes, threshold values, clinical staging — ARE preserved as part of the item, kept as concise as possible (shortened or trimmed where needed to fit the one-page budget, but never dropped entirely).	🟢	Drug lists retained for OTC, anticoagulants, calcineurin inhibitors
9.6	When the ER uses ranking notation inside parens (e.g., “>” for severity ordering) that depends on an explanatory phrase to interpret, normalize the items to a plain comma-separated list rather than carrying through the bare symbol.	N/A	ER caution bullets do not use ranking notation
9.7	If no [caution_items] are present the section is left empty	N/A	caution_items are present

10. Protocol

#	Description	Result	Comments
10.1	The section is derived from the ER Protocol section	🟢	From Therapeutic Protocol
10.2	The three sets of [action] items cover the three most important actionable implementation aspects from the ER Protocol section	🟢	Form, Application (2–4× daily), Concentration/course
10.3	If less that three distinct actionable implementation aspects are mentioned in the ER the unused sets are left empty and made invisible, not filled with placeholder text or empty-state phrasing.	N/A	Three action sets are used
10.4	All used [action_#label], [action#value], [action#_sub] items are filled with meaningful content derived from the ER Protocol section.	🟢

11. Time to Effect

#	Description	Result	Comments
11.1	The three sets of [time] items cover the three most important time-to-effect aspects from the ER	🟢	Matches Practical Considerations: multi-week radiation, 1–2 weeks acute wound, hours–days soothing
11.2	The sets are picked and ordered by the magnitude of the related benefit	🟢	Radiation skin support → acute wound → local soothing
11.3	If less that three distinct time-to-effect aspects are mentioned in the ER the unused sets are left empty and made invisible, not filled with placeholder text or empty-state phrasing.	N/A	Three time sets are used
11.4	All used [time_#label], [time#value], [time#_sub] items are filled with meaningful content derived from the ER.	🟢
11.5	If the ER does not provide any information on time to effect, the section is removed completely from the Protocol Panel	N/A	ER provides time-to-effect information

12. Benefits

#	Description	Result	Comments
12.1	The section is derived from the ER Expected Benefits section	🟢
12.2	Key variables are [benefits_high], [benefits_medium], [benefits_low], [benefits_speculative]	🟢
12.3	Items are as concise as possible. No explanations, no elaborations, no effect sizes, no qualifiers, no attributions, no citations, no study details, no mechanistic explanations, etc. Just the key fact.	🟢
12.4	Parenthetical content — including effect sizes, sample notes, mechanistic hints, and example studies — is stripped, NOT preserved.	🟢	e.g., (epithelialization), (episiotomy), (oropharyngeal), (photoprotection) stripped
12.5	If no items of a specific sub-section (high, medium, low, speculative) are present the respective is set to “display=none”, not filled with “None documented in human trials to date” or similar empty-state phrasing.	🟢	benefits_high has style=”display:none”

13. Risks

#	Description	Result	Comments
13.1	The section is derived from the ER Potential Risks & Side Effects section	🟢
13.2	Key variables are [risks_high], [risks_medium], [risks_low], [risks_speculative]	🟢
13.3	Items are as concise as possible. No explanations, no elaborations, no effect sizes, no qualifiers, no attributions, no citations, no study details, no mechanistic explanations, etc. Just the key fact.	🟢
13.4	Parenthetical content — including frequencies, severity grades, sample notes, mechanistic hints, and example studies — is stripped, NOT preserved.	🟢	Asteraceae/Compositae parenthetical stripped from high-risk title
13.5	If no items of a specific sub-section (high, medium, low, speculative) are present the respective is set to “display=none”, not filled with “None documented in human trials to date” or similar empty-state phrasing.	🟢	All risk tiers have items

14. Monitoring

#	Description	Result	Comments
14.1	The section is derived from the ER Monitoring section	🟢	From Monitoring Protocol & Defining Success
14.2	All measurable/quantifiable biomarkers from the Monitoring section are listed	🟢	All five table biomarkers present
14.3	[monitoring_cadence] is populated with the monitoring cadence/frequency derived from the ER Monitoring section. It is not left with placeholder text or empty.	🟢	Matches ER daily/weekly/1–2 week cadence

15. Qualitative Assessment

#	Description	Result	Comments
15.1	The section is derived from the ER Monitoring section	🟢
15.2	All subjective/qualitative biomarkers from the Monitoring section are listed	🟢	All four qualitative markers present

Issues 09/08/2026 17:59

Pass rate 100.00%. No issues found.

Issues 09/08/2026 17:48

1. 10.4 — Protocol content off-section: action_2_value includes “Thin layer” from Risk Mitigation Strategies, and action_3_sub leads with “Short-term for defined wound, rash, or radiotherapy course (days to weeks)” from Discontinuation & Cycling rather than Therapeutic Protocol.

Fixes 09/08/2026 17:48

1. 10.4 — Protocol content off-section: Removed “Thin layer” from action_2_value (now “2–4× daily” from Protocol dosing). Replaced action_3_sub Discontinuation duration phrase with Protocol-only course language: tincture range plus continue until epithelialization or throughout radiotherapy.

Issues 09/08/2026 17:31

1. 1.1 — Unsupported tincture claim: action_3_sub states “2%–20% tincture for intact skin”. The ER places 2%–20% tincture under wound-care concentration ranges and separately recommends hydroalcoholic tincture for intact skin without that percentage; the combined claim is not literally supported.

Fixes 09/08/2026 17:40

1. 1.1 — Protocol tincture claim: Replaced action_3_sub “2%–20% tincture for intact skin” with “2%–20% tincture as studied for wound care” to match ER wound-care concentration ranges.

Issues 09/08/2026 17:27

1. 7.4 — Systemic jargon in at-a-glance: The phrase “Not a systemic longevity drug” uses clinical-register “systemic”; a non-specialist would not use that term unprompted.

2. 10.4 — Protocol sub from non-Protocol sections: action_1_sub includes “not Tagetes marigold” (Sourcing / Practical Considerations / Historical Context) and “prefer ointment over high-alcohol tincture on open skin” (Risk Mitigation Strategies) rather than content derived from the Therapeutic Protocol section.

Fixes 09/08/2026 17:27

1. 7.4 — Systemic jargon in at-a-glance: Replaced “Not a systemic longevity drug” with “Not a whole-body longevity treatment” in at_a_glance.

2. 10.4 — Protocol sub non-Protocol content: Rewrote action_1_sub from Therapeutic Protocol only: “Flower-based ointment, cream, or oily extract as studied for skin support” (removed Tagetes and risk-mitigation tincture preference).

Issues 09/08/2026 17:19

1. 8.5 — Children age thresholds dropped: Children stop-item drops ER parenthetical age thresholds (often ≥6 years for skin, ≥12 years for mouth/throat products); only ‘under labeled monograph ages’ remains.

Fixes 09/08/2026 17:20

1. 8.5 — Children age thresholds: Restored ER parenthetical age thresholds on the children stop-item: now “Children under labeled monograph ages (often ≥6 years for skin, ≥12 years for mouth/throat products)”.

Issues 09/08/2026 17:12

1. 1.3 — Pregnancy caution strengthened: Oral pregnancy/lactation is listed as an unqualified Contraindication stop item; the ER frames it as traditional caution under populations who should avoid or restrict.

2. 2.7 — Specialist medical jargon: action_2_sub uses “radiodermatitis” and time_2_sub uses “epithelialization” without plain-language alternatives.

3. 8.5 — Pregnancy stop qualifiers dropped: The pregnancy/lactation stop item omits the ER severity qualifier “(traditional caution)” and the large-area topical clinician-input restriction from the same bullet.

4. 9.4 — Caution item elaboration: First Key Interaction keeps “(additive irritation)”, which is consequence elaboration rather than an allowed parenthetical qualifier.

5. 11.2 — Time-to-effect order: Sets are ordered chronologically (local soothing → acute wound → radiation) instead of by related benefit magnitude (Medium-tier radiation and acute wound before general local soothing).

Fixes 09/08/2026 17:14

1. 1.3 / 8.5 — Pregnancy stop qualifiers restored: Rewrote the oral pregnancy/lactation stop item to keep ER “(traditional caution)” and the large-area topical clinician-input restriction.

2. 2.7 — Plain-language jargon: Replaced “radiodermatitis” with “radiation-skin” in action_2_sub and “epithelialization” with “surface-healing” in time_2_sub.

3. 9.4 — Caution elaboration removed: Dropped the trailing “(additive irritation)” consequence phrase from the sedating/photosensitizing topicals Key Interaction item.

4. 11.2 — Time-to-effect reordered: Reordered sets by related benefit magnitude: radiation skin support, then acute wound coverage, then local soothing.