Audit: QRS - Indole-3-Carbinol for Health & Longevity
Audit conducted on 17/06/2026 06:06 using AI4L / Opus 4.8
Summary
| Items | Count |
|---|---|
| Total | 91 |
| Passed | 85 |
| Failed | 0 |
| N/A | 6 |
| Pass Rate | 100.00% |
- Total = Passed + Failed + N/A
- Pass Rate = Passed / (Passed + Failed) × 100
- N/A items are excluded from the pass rate calculation
1. General Rules
| # | Description | Result | Comments |
|---|---|---|---|
| 1.1 | Every claim, magnitude, label, recommendation, and statement in the QRS is literally supported by content in the source ER. | 🟢 | All QRS content traces to ER passages. |
| 1.2 | Where the ER uses cautious phrasing (“not formally studied”, “None documented in human trials to date”, “theoretical concern”, “data are limited”), the QRS uses the same phrasing. | 🟢 | At-a-glance “proven disease benefit remains unestablished” mirrors ER caution. |
| 1.3 | The QRS never strengthens an ER claim (e.g., “not formally studied” → “not required”) or softens one (e.g., “do not use during pregnancy” → “use with caution during pregnancy”). | 🟢 | Contraindications and benefit framing preserve ER strength. |
| 1.4 | The QRS does not relabel an ER fact under a different decision category. | 🟢 | Benefits, risks, interactions, contraindications map to matching ER sections. |
| 1.5 | PubMed IDs, study citations, expert names, clinical trial identifiers (NCT*), and brand names appear in the QRS only if they appear in the source ER for the same fact. | 🟢 | No citations or NCT IDs introduced in the QRS. |
| 1.6 | The QRS does not introduce new attributions. | 🟢 | No new attributions present. |
2. Focus, Tone & Audience
| # | Description | Result | Comments |
|---|---|---|---|
| 2.1 | The QRS follows the tone of the ER, which is determined by the ER’s own language, phrasing, and framing. | 🟢 | Objective, measured tone matches ER. |
| 2.2 | The tone of the QRS is simultaneously expert, accessible, objective, and data-driven, but also empowering and encouraging | 🟢 | Tone satisfied throughout. |
| 2.3 | The QRS reads as a trusted, knowledgeable guide rather than a prescriptive doctor | 🟢 | Presents evidence, not orders. |
| 2.4 | The QRS avoids language that implies medical or clinical advice | 🟢 | No directive medical advice. |
| 2.5 | The QRS “presents information” instead of “providing guidance”, “recommending”, or “advising” | 🟢 | Information-presenting voice. |
| 2.6 | The QRS never addresses “the reader” directly — it presents evidence, not guidance | 🟢 | No second-person address found. |
| 2.7 | The QRS is written in plain language, avoiding unnecessary medical jargon | 🟢 | Jargon expanded or avoided. |
| 2.8 | Information is presented in a concise and very compact manner | 🟢 | Compact card layout. |
| 2.9 | It DOES NOT address the reader directly | 🟢 | No “you/your” in content. |
| 2.10 | The target audience is health- and longevity-oriented adults who are risk-aware, proactive, and actively seeking to optimize health or apply the intervention under review. | 🟢 | Framing fits this audience. |
| 2.11 | The target audience is willing to employ lifestyle and behavioral changes as well as follow protocols that may be inconvenient, costly, or require effort. | 🟢 | Monitoring/protocol detail assumes engaged audience. |
| 2.12 | The document is NOT written for the general population, who are unwilling to employ lifestyle and behavioral changes or follow protocols that may be inconvenient, costly, or require effort. | 🟢 | Not written for general population. |
| 2.13 | Framing, takeaways, and risk/benefit weighting throughout the document reflect this audience, including where an intervention’s signal for the average person differs from its signal for this audience. | 🟢 | Weighting reflects proactive audience. |
| 2.14 | The document’s own voice frames usage in longevity terms, not “anti-aging”. Proper names that contain “anti-aging” are quoted verbatim. | 🟢 | Uses “longevity”; no “anti-aging”. |
| 2.15 | The document’s own voice uses formal clinical and scientific terminology, not colloquial or consumer-grade language. Direct quotes from sources are exempt. | 🟢 | Formal terminology used. |
3. Template Integrity
| # | Description | Result | Comments |
|---|---|---|---|
| 3.1 | The following labels and headings on the QRS are fixed and not modified: Card/section headings, Gate headings, Tier labels, Monitoring table column headers. | 🟢 | All fixed headings present (note “Risk & Side Effects” matches template). |
| 3.2 | All “…” from the [qrs_template] are present in the QRS. | 🟢 | All template spans present; repeating marker/qualitative spans expanded. |
| 3.3 | Spans that are not addressed in a checklist item are left unchanged | 🟢 | No unrelated spans modified. |
4. Formatting
| # | Description | Result | Comments |
|---|---|---|---|
| 4.1 | When the source ER section is empty, the QRS uses the ER’s own empty-state phrasing verbatim. | N/A | No relevant ER source section is empty. |
| 4.2 | Where the ER presents a bulleted item as “Label: content”, the QRS uses the ER’s bold label verbatim as the cell or row label. | 🟢 | Protocol/monitoring labels match ER. |
| 4.3 | Labels are not paraphrased, abbreviated, or invented. | 🟢 | Labels faithful to ER. |
| 4.4 | The QRS DOES NOT use emoji indicators (no 🟩, 🟥, 🟨, etc.). | 🟢 | No emoji indicators in QRS body. |
| 4.5 | The QRS is designed to render on one A4 page. Any section with more content than fits is condensed, not extended onto a second page. | 🟢 | Content condensed to one page. |
5. Metadata
| # | Description | Result | Comments |
|---|---|---|---|
| 5.1 | The metadata is placed inside a single HTML comment that is the first element after “<!doctype html>” and before any other comment, head, or body content. | 🟢 | Metadata comment is first element (lines 2-14). |
| 5.2 | Inside that HTML comment the YAML block is delimited by a line “—” opening and a line “—” closing. | 🟢 | YAML delimited correctly. |
| 5.3 | The metadata is not visible in any rendered view of the QRS and is not surfaced by any other element on the sheet. | 🟢 | Inside HTML comment; not rendered. |
| 5.4 | All frontmatter values are trimmed: no leading/trailing whitespace, no surrounding quotes unless required by YAML. | 🟢 | Values trimmed; duration quoted (contains colon). |
| 5.5 | The filename of the source ER is stated as “er_filename: [er_filename]”. | 🟢 | er_filename: indole_3_carbinol_2026-0617-0521_Opus_ER.md |
| 5.6 | Version of the QRS.md file used to create the document is stated as “qrs_prompt_version: [Version of QRS.md]”. | 🟢 | qrs_prompt_version: 26.5.18 |
| 5.7 | Creation date and time of the document is stated as “qrs_creation_date: [YYYY-MMDD-HHMM]”. | 🟢 | qrs_creation_date: 2026-0617-0521 |
| 5.8 | The nickname of the AI used to create the document is stated as “qrs_creator_ai_nickname: [qrs_creator_ai_nickname]”. | 🟢 | qrs_creator_ai_nickname: Opus |
| 5.9 | The nickname of the AI is just a single word model name without version, etc. | 🟢 | “Opus”. |
| 5.10 | The full name of the AI used to create the document is stated as “qrs_creator_ai_fullname: [qrs_creator_ai_fullname]”. | 🟢 | qrs_creator_ai_fullname: Opus 4.8 |
| 5.11 | The full name of the AI consists of the nickname and the model version number and no additional qualifier. | 🟢 | “Opus 4.8”. |
| 5.12 | The filename of the document is stated as “qrs_filename: [filename of this document]”. | 🟢 | qrs_filename: indole_3_carbinol_2026-0617-0521_Opus_QRS.html |
| 5.13 | All frontmatter values are trimmed: no leading/trailing whitespace, no surrounding quotes unless required by YAML. | 🟢 | Frontmatter clean and consistent. |
6. Page Title & Header
| # | Description | Result | Comments |
|---|---|---|---|
| 6.1 | [page_title] is set to the [canonical_topic] followed by “ - Quick Reference Sheet”, HTML-entity-encoded as needed. | 🟢 | “Indole-3-Carbinol for Health & Longevity - Quick Reference Sheet”. |
| 6.2 | [header_topic] is set to the [canonical_topic], with HTML entities encoded as needed. | 🟢 | “Indole-3-Carbinol for Health & Longevity”. |
| 6.3 | [header_subline_date] is set to [qrs_creation_date reformatted as MM/DD/YYYY]. | 🟢 | “06/17/2026”. |
| 6.4 | [header_subline_model] is set to [qrs_creator_ai_fullname]. | 🟢 | “Opus 4.8”. |
| 6.5 | No additional header content appears: no badge, version stamp, AKA line, source-AI attribution, audit date, or QRS variant marker. | 🟢 | Header clean; no extra content. |
7. At-A-Glance Section
| # | Description | Result | Comments |
|---|---|---|---|
| 7.1 | [at_a_glance] is dense, execution-oriented summary of the ER Conclusion section. |
🟢 | Distills the ER Conclusion (lines 412-416). |
| 7.2 | [at_a_glance] is no longer than 60 words. | 🟢 | 51 words. |
| 7.3 | Every fact in [at_a_glance] is supported by a distinct passage in the ER. | 🟢 | Each clause traces to a Conclusion passage. |
| 7.4 | It DOES NOT use acronyms or technical classifications that require specialist knowledge, uses plain-language terms instead. | 🟢 | Plain-language; no specialist acronyms. |
| 7.5 | It DOES NOT cite specific trials (names, years, sample sizes, p-values). | 🟢 | No trial names/years/sizes cited. |
| 7.6 | It DOES NOT cite effect sizes, relative risks, or statistical results. | 🟢 | No effect sizes or statistics. |
8. Contraindications
| # | Description | Result | Comments |
|---|---|---|---|
| 8.1 | The section is derived from the ER Key Interactions & Contraindications section. |
🟢 | Derived from ER lines 262-274. |
| 8.2 | [stop_items] represent the Contraindications from the ER. | 🟢 | Pregnancy/breastfeeding, active hormone-sensitive cancer, children (ER line 274). |
| 8.3 | Individual [stop_items] are formatted as <li></li>. | 🟢 | Three <li> items. |
| 8.4 | Items are as concise as possible. No trailing explanations, elaborations, rationale, attributions, citations, study details, or content after a dash. | 🟢 | Concise; no trailing clauses. |
| 8.5 | Parenthetical qualifiers from the ER bullet are preserved as part of the item, kept concise. | 🟢 | No essential qualifiers dropped. |
| 8.6 | When the ER uses ranking notation inside parens that depends on an explanatory phrase, normalize to a plain comma-separated list. | 🟢 | ER uses no ranking notation; nothing to normalize. |
| 8.7 | If no [stop_items] are present the section is left empty. | N/A | Stop items are present. |
9. Key Interactions
| # | Description | Result | Comments |
|---|---|---|---|
| 9.1 | The section is derived from the ER Key Interactions & Contraindications section. |
🟢 | Derived from ER lines 264-272. |
| 9.2 | [caution_items] represent the Key Interactions from the ER, excluding any already listed as Contraindications. | 🟢 | Six interaction items; no contraindication overlap. |
| 9.3 | Individual [caution_items] are formatted as <li></li>. | 🟢 | Six <li> items. |
| 9.4 | Items are as concise as possible. No trailing explanations, elaborations, rationale, attributions, citations, study details, or content after a dash. | 🟢 | Concise; example drugs kept in parens only. |
| 9.5 | Parenthetical qualifiers from the ER bullet — example drug lists, etc. — are preserved, kept concise. | 🟢 | Example drug lists preserved concisely. |
| 9.6 | When the ER uses ranking notation inside parens that depends on an explanatory phrase, normalize to a plain comma-separated list. | 🟢 | ER uses no ranking notation; nothing to normalize. |
| 9.7 | If no [caution_items] are present the section is left empty. | N/A | Caution items are present. |
10. Protocol
| # | Description | Result | Comments |
|---|---|---|---|
| 10.1 | The section is derived from the ER Protocol section. |
🟢 | Derived from ER Therapeutic Protocol (lines 296-319). |
| 10.2 | The three sets of [action] items cover the three most important actionable implementation aspects from the ER Protocol section. |
🟢 | Dose, Form, Timing. |
| 10.3 | If less than three distinct actionable aspects are mentioned, unused sets are left empty and invisible. | N/A | Three aspects are present. |
| 10.4 | All used [action_#label], [action#value], [action#_sub] items are filled with meaningful content derived from the ER Protocol section. |
🟢 | All three sets populated from ER. |
11. Time to Effect
| # | Description | Result | Comments |
|---|---|---|---|
| 11.1 | The three sets of [time] items cover the three most important time-to-effect aspects from the ER. | 🟢 | Estrogen-metabolism shift, cervical-lesion regression, any clinical change (ER line 351). |
| 11.2 | The sets are picked and ordered by the magnitude of the related benefit. | 🟢 | Ordered biomarker → cervical endpoint → general clinical change. |
| 11.3 | If less than three distinct time-to-effect aspects are mentioned, unused sets are left empty and invisible. | N/A | Three aspects are present. |
| 11.4 | All used [time_#label], [time#value], [time#_sub] items are filled with meaningful content derived from the ER. | 🟢 | All three sets populated. |
| 11.5 | If the ER does not provide any information on time to effect, the section is removed completely from the Protocol Panel. |
N/A | ER provides time-to-effect information (line 351). |
12. Benefits
| # | Description | Result | Comments |
|---|---|---|---|
| 12.1 | The section is derived from the ER Expected Benefits section. |
🟢 | Derived from ER lines 144-190. |
| 12.2 | Key variables are [benefits_high], [benefits_medium], [benefits_low], [benefits_speculative]. | 🟢 | All four variables present. |
| 12.3 | Items are as concise as possible. No explanations, effect sizes, qualifiers, attributions, citations, study details, or mechanistic explanations. | 🟢 | Bare benefit phrases only. |
| 12.4 | Parenthetical content — effect sizes, sample notes, mechanistic hints, example studies — is stripped, NOT preserved. | 🟢 | No parentheticals carried over. |
| 12.5 | If no items of a sub-section are present the respective span is set to “display=none”, not filled with empty-state phrasing. | 🟢 | High tier empty → display:none; no empty-state text. |
13. Risks
| # | Description | Result | Comments |
|---|---|---|---|
| 13.1 | The section is derived from the ER Potential Risks & Side Effects section. |
🟢 | Derived from ER lines 206-246. |
| 13.2 | Key variables are [risks_high], [risks_medium], [risks_low], [risks_speculative]. | 🟢 | All four variables present. |
| 13.3 | Items are as concise as possible. No explanations, effect sizes, qualifiers, attributions, citations, study details, or mechanistic explanations. | 🟢 | Bare risk phrases only. |
| 13.4 | Parenthetical content — frequencies, severity grades, sample notes, mechanistic hints, example studies — is stripped, NOT preserved. | 🟢 | No parentheticals carried over. |
| 13.5 | If no items of a sub-section are present the respective span is set to “display=none”, not filled with empty-state phrasing. | 🟢 | High tier empty → display:none; no empty-state text. |
14. Monitoring
| # | Description | Result | Comments |
|---|---|---|---|
| 14.1 | The section is derived from the ER Monitoring section. |
🟢 | Derived from ER table (lines 379-385). |
| 14.2 | All measurable/quantifiable biomarkers from the Monitoring section are listed. |
🟢 | All five biomarkers listed. |
| 14.3 | [monitoring_cadence] is populated with the cadence/frequency derived from the ER Monitoring section. It is not left placeholder or empty. |
🟢 | Cadence matches ER line 377. |
15. Qualitative Assessment
| # | Description | Result | Comments |
|---|---|---|---|
| 15.1 | The section is derived from the ER Monitoring section. |
🟢 | Derived from ER qualitative markers (lines 387-392). |
| 15.2 | All subjective/qualitative biomarkers from the Monitoring section are listed. |
🟢 | All four qualitative markers listed. |
Issues 17/06/2026 06:06
Pass rate 100.00%. No issues found.
Issues 17/06/2026 06:01
- 15.2 — Qualitative cue trimmed: ER line 392 lists “Any neurological symptoms such as balance disturbance (a flag to reduce dose)”; the QRS qualitative_item_4 (line 673) drops the “(a flag to reduce dose)” cue. All four markers are otherwise present and faithful.
Fixes 17/06/2026 06:01
- 15.2 — Restored qualitative cue: Re-added the ER’s “(a flag to reduce dose)” cue to qualitative_item_4 so the neurological-symptoms marker matches the ER (line 392) verbatim.
Issues 17/06/2026 05:57
- 13.4 — Parenthetical not stripped in Risks: risks_speculative (line 579) retains the parenthetical “(goitrogenic)” in “Thyroid (goitrogenic) concern”; item 13.4 requires parenthetical content in the Risks section to be stripped, not preserved.
Fixes 17/06/2026 05:57
- 13.4 — Parenthetical stripped in Risks: Removed the parenthetical “(goitrogenic)” from the risks_speculative item; “Thyroid (goitrogenic) concern” changed to “Thyroid concern”.