Luteolin is a plant flavone with laboratory support for calming inflammation and oxidative stress. The clearest human evidence is for combinations with palmitoylethanolamide plus smell training after viral smell loss. Standalone use for broad longevity claims remains under-proven. Usual doses appear well tolerated; product formulation strongly affects how much is absorbed. (Full Review)
| Marker | Target | Why |
|---|---|---|
| hs-CRP | <1.0 mg/L (functional often <0.5–1.0) | Tracks systemic inflammatory tone that luteolin aims to influence |
| ALT / AST | ALT ideally <25–30 U/L (sex-dependent); avoid rising trends | Hepatic safety with polyphenols and polypharmacy |
| GGT | Lower within lab range; functional often <20–30 U/L | Extra hepatic/oxidative stress context |
| eGFR / creatinine | eGFR ≥90 mL/min/1.73 m² preferred; investigate sustained decline | Baseline renal clearance context |
| Fasting glucose / HbA1c | Glucose ~70–90 mg/dL; HbA1c ~4.8–5.3% (individualize) | Metabolic context if metabolic benefit is a goal |
| CBC | Within lab reference; watch unexpected cytopenias | General safety screen |
| INR (if on warfarin) | Per anticoagulation clinic target | Detect CYP2C9-related interaction |
Cadence: Check-in at 2 weeks (tolerability), 4–8 weeks (early benefit), and 12 weeks (continue vs. stop); labs every 3–6 months if long-term or higher risk