Phosphatidylethanolamine is a core cell-membrane fat, especially rich in mitochondria and the brain, and is required for energy production and cellular recycling. Taking extra phosphatidylethanolamine as a stand-alone oral supplement has not been shown to improve human healthspan. People usually obtain it from ordinary foods and mixed lecithin products; food and typical lecithin intakes appear generally well tolerated. (Full Review)
| Marker | Target | Why |
|---|---|---|
| ALT / AST | ALT often aimed ~<25–30 U/L (functional) | Hepatic stress relevant to PC/PE biology |
| GGT | Often aimed lower within lab range (e.g., <30 U/L) | Oxidative / biliary hepatic stress |
| Fasting lipid panel | Context-dependent; ApoB often prioritized | Lipoprotein export ties to hepatic PC |
| Homocysteine | Often aimed <8–10 µmol/L functionally | PEMT methyl demand / one-carbon status |
| Serum B12 / folate | Mid-to-upper reference / RBC folate adequate | Methylation capacity for PE→PC |
| Plasma choline (if available) | Lab-specific; low values flag intake/synthesis issues | Substrate partner to PE economy |
| Hs-CRP | Often aimed <1.0 mg/L | Systemic inflammation context |
| Ferritin / iron studies | Sex- and age-specific mid-range | Iron load relevant to ferroptosis theory |
Cadence: Baseline metabolic/hepatic panel, fasting lipids, homocysteine, and B12/folate before multi-gram phospholipid emphasis; recheck hepatic enzymes, lipids, and homocysteine at ~8–12 weeks after a major intake change, then every 6–12 months if continued (sooner if symptoms or pre-existing liver disease)