Audit: QRS - Progesterone for Health & Longevity
Audit conducted on 04/08/2026 05:54 using AI4L / Opus 5
Summary
| Items | Count |
|---|---|
| Total | 91 |
| Passed | 81 |
| Failed | 0 |
| N/A | 10 |
| Pass Rate | 100.00% |
- Total = Passed + Failed + N/A
- Pass Rate = Passed / (Passed + Failed) × 100
- N/A items are excluded from the pass rate calculation
1. General Rules
| # | Description | Result | Comments |
|---|---|---|---|
| 1.1 | Every claim, magnitude, label, recommendation, and statement in the QRS is literally supported by content in the source ER. | 🟢 | All 12 contraindications, 8 interactions, 15 benefit items, 15 risk items, 10 biomarkers, 7 qualitative markers, 3 protocol cells and 3 time-to-effect cells trace to ER lines 148–231, 242–334, 345–356, 370–382, 402, 418–441, 455. |
| 1.2 | Where the ER uses cautious phrasing (“not formally studied”, “None documented in human trials to date”, “theoretical concern”, “data are limited”), the QRS uses the same phrasing. | 🟢 | Hedges preserved: “Probable dementia carried over from the progestin class boxed warning”, “Meningioma signal attaching to the progestogen class”, “Trials support…”, “look better than”. |
| 1.3 | The QRS never strengthens an ER claim (e.g., “not formally studied” → “not required”) or softens one (e.g., “do not use during pregnancy” → “use with caution during pregnancy”). | 🟢 | Speculative tier retained as speculative; “no endometrial protection from transdermal creams” carried at full strength as in ER line 254. |
| 1.4 | The QRS does not relabel an ER fact under a different decision category. A “Benefit-Modifying Factor” from ER section is not surfaced as a “Caution”; a “Risk-Modifying Factor” is not surfaced as a “Side Effect”; etc. | 🟢 | Contraindications gate draws only from ER lines 355–356; Key Interactions gate only from ER lines 347–354; no Benefit- or Risk-Modifying Factor content appears in either gate. |
| 1.5 | PubMed IDs, study citations, expert names, clinical trial identifiers (NCT*), and brand names appear in the QRS only if they appear in the source ER for the same fact. | 🟢 | No PMIDs, NCT identifiers, expert names (Prior, Stute, Wright) or brand names (Prometrium, Utrogestan, Bijuva) appear in the QRS. |
| 1.6 | The QRS does not introduce new attributions. | 🟢 | No attributions of any kind in the QRS. |
2. Focus, Tone & Audience
| # | Description | Result | Comments |
|---|---|---|---|
| 2.1 | The QRS follows the tone of the ER, which is determined by the ER’s own language, phrasing, and framing. | 🟢 | Neutral, evidence-first register matching the ER throughout. |
| 2.2 | The tone of the QRS is simultaneously expert, accessible, objective, and data-driven, but also empowering and encouraging | 🟢 | Thresholds and dose ranges given without alarm or promotion. |
| 2.3 | The QRS reads as a trusted, knowledgeable guide rather than a prescriptive doctor | 🟢 | Protocol cells describe regimens as used and tested, not as instructions issued to a patient. |
| 2.4 | The QRS avoids language that implies medical or clinical advice | 🟢 | No imperative clinical directives in the document’s own voice. |
| 2.5 | The QRS “presents information” instead of “providing guidance”, “recommending”, or “advising” | 🟢 | No occurrences of “recommend”, “advise”, “should”, or “we suggest” in any variable region. |
| 2.6 | The QRS never addresses “the reader” directly — it presents evidence, not guidance | 🟢 | No second-person pronouns in any data-qrs-var region. |
| 2.7 | The QRS is written in plain language, avoiding unnecessary medical jargon | 🟢 | Technical terms retained only where they are the decision-relevant fact (CYP3A4, Child-Pugh Class C); everything else in plain terms. |
| 2.8 | Information is presented in a concise and very compact manner | 🟢 | Benefit and risk lines reduced to ER headings; gate items reduced to the key fact. |
| 2.9 | It DOES NOT address the reader directly | 🟢 | Confirmed — impersonal construction throughout (“Driving or working within several hours of dosing”). |
| 2.10 | The target audience is health- and longevity-oriented adults who are risk-aware, proactive, and actively seeking to optimize health or apply the intervention under review. | 🟢 | Functional biomarker targets and self-tracked qualitative markers are pitched at this audience. |
| 2.11 | The target audience is willing to employ lifestyle and behavioral changes as well as follow protocols that may be inconvenient, costly, or require effort. | 🟢 | Bedtime-only dosing constraint and daily symptom scoring presented without hedging on inconvenience. |
| 2.12 | The document is NOT written for the general population, who are unwilling to employ lifestyle and behavioral changes or follow protocols that may be inconvenient, costly, or require effort. | 🟢 | Monitoring panel of ten markers and cyclic dosing schedules assume a committed reader. |
| 2.13 | Framing, takeaways, and risk/benefit weighting throughout the document reflect this audience, including where an intervention’s signal for the average person differs from its signal for this audience. | 🟢 | The transdermal-cream failure mode and the five-year evidence horizon are both surfaced prominently, which is the distinction that matters to this audience. |
| 2.14 | The document’s own voice frames usage in longevity terms, not “anti-aging” (e.g., “anti-aging clinics”, “anti-aging community”, “anti-aging medicine”). Proper names that contain “anti-aging” (e.g., “American Academy of Anti-Aging Medicine”) are quoted verbatim. | 🟢 | “longevity strategy” used in benefits_speculative; no occurrence of “anti-aging”. |
| 2.15 | The document’s own voice uses formal clinical and scientific terminology, not colloquial or consumer-grade language (e.g., “oral medication” not “pill(s)”; “injection” not “shot”; “adverse event” not “bad reaction”). Direct quotes from sources are exempt. | 🟢 | “capsule excipients”, “arterial thromboembolic disease”, “hepatic impairment” used correctly; the plainer register in At-A-Glance is mandated by item 7.4. |
3. Template Integrity
| # | Description | Result | Comments |
|---|---|---|---|
| 3.1 | The following labels and headings on the QRS are fixed and not modified: Card and section headings: “Protocol”, “Time to effect”, “Benefits”, “Risk & Side Effects”, “Monitoring”, “Qualitative Assessment”; Gate headings: “Contraindications”, “Key Interactions”; Tier labels: “High”, “Medium”, “Low”, “Speculative”; Table column headers in Monitoring: “Marker”, “Target”, “Why” | 🟢 | All fixed labels verified verbatim at QRS lines 446, 492, 542, 572, 591, 611, 646, 650–652, 780 and in both tier blocks. |
| 3.2 | All “…” from the [qrs_template] are present in the the QRS. | 🟢 | 4 header/title spans, at_a_glance, 9 action spans, 9 time spans, 4 benefits spans, stop_items, caution_items, 4 risks spans, 30 marker spans, monitoring_cadence and 7 qualitative spans all present. |
| 3.3 | Spans that are not addressed in a checklist item are left unchanged | 🟢 | The website="evidence_review", website="audit" and website="full_review" placeholders and the footer disclaimer are untouched. |
4. Formatting
| # | Description | Result | Comments |
|---|---|---|---|
| 4.1 | When the source ER section is empty, the QRS uses the ER’s own empty-state phrasing verbatim. Typical phrasings are “None documented in human trials to date” and “Not formally studied” | N/A | No source ER section that feeds the QRS is empty; every tier, gate, biomarker and qualitative list is populated in the ER. |
| 4.2 | Where the ER presents a bulleted item as “Label: content”, the QRS uses the ER’s bold label verbatim as the cell or row label. | 🟢 | “Standard endometrial-protection regimen”, “Symptom-directed monotherapy” and “Best time of day” match the ER bold labels at lines 372, 373 and 375 verbatim. |
| 4.3 | Labels are not paraphrased, abbreviated, or invented. | 🟢 | Biomarker names match the ER table’s Biomarker column; tier labels and protocol labels are ER-sourced. |
| 4.4 | The QRS DOES NOT use emoji indicators (no 🟩, 🟥, 🟨, etc.). Color and emphasis are conveyed through CSS and bold labels. | 🟢 | No emoji present anywhere in the QRS; tiers conveyed by bold text plus CSS palette. |
| 4.5 | The QRS is designed to render on one A4 page. Any section that has more content in the ER than fits the per-section budget is condensed by the LLM, not extended onto a second page. | 🟢 | Every section is condensed to headline level — a 460-line ER reduced to single-clause gate items, ER-heading-only benefit and risk lines, and one-line biomarker rationales. |
5. Metadata
| # | Description | Result | Comments |
|---|---|---|---|
| 5.1 | The metadata is placed inside a single HTML comment that is the first element after “<!doctype html>” and before any other comment, head, or body content. | 🟢 | Lines 2–14, immediately after the doctype at line 1. |
| 5.2 | Inside that HTML comment the YAML block is delimited by a line “—” opening and a line “—” closing. Text before the opening “—” is permitted but is not parsed as YAML. | 🟢 | Opening --- at line 3, closing --- at line 13; the “QRS — Metadata” caption precedes the opening delimiter. |
| 5.3 | The metadata is not visible in any rendered view of the QRS and is not surfaced by any other element on the sheet. | 🟢 | Enclosed in an HTML comment; no metadata value is repeated in the header or footer. |
| 5.4 | All frontmatter values are trimmed: no leading or trailing whitespace, no surrounding quotes unless the value contains a colon, bracket, or leading special character that requires YAML quoting. | 🟢 | Only duration: "00:04" is quoted, correctly, because it contains a colon. |
| 5.5 | The filename of the source ER is stated as “er_filename: [er_filename]” | 🟢 | Line 4: er_filename: progesterone_2026-0804-0038_Opus_ER.md. |
| 5.6 | Version of the QRS.md file used to create the document is stated as “qrs_prompt_version: [Version of QRS.md]” | 🟢 | Line 5: 26.7.02, matching the QRS.md version badge. |
| 5.7 | Creation date and time of the document is stated as “qrs_creation_date: [YYYY-MMDD-HHMM]” (e.g., 2026-0501-1430) | 🟢 | Line 6: 2026-0804-0520, correct format. |
| 5.8 | The nickname of the AI used to create the document is stated as “qrs_creator_ai_nickname: [qrs_creator_ai_nickname]” | 🟢 | Line 7: Opus. |
| 5.9 | The nickname of the AI is just a single word model name without version, etc. (e.g., Opus, Sonnet, Grok, Gemini, ChatGPT) | 🟢 | Single word, no version or qualifier. |
| 5.10 | The full name of the AI used to create the document is stated as “qrs_creator_ai_fullname: [qrs_creator_ai_fullname]” | 🟢 | Line 8: Opus 5. |
| 5.11 | The full name of the AI consists of the [qrs_creator_ai_nickname] and the model version number and no additional qualifier (e.g., Opus 4.6, Sonnet 3.2, Grok 4.5, Gemini 3.1, ChatGPT 5.4) | 🟢 | “Opus 5” — nickname plus version, no context-window or other qualifier appended. |
| 5.12 | The filename of the document is stated as “qrs_filename: [filename of this document]” | 🟢 | Line 9 matches the file’s actual name on disk. |
| 5.13 | All frontmatter values are trimmed: no leading or trailing whitespace, no surrounding quotes unless the value contains a colon, bracket, or leading special character that requires YAML quoting. | 🟢 | Re-verified across all eight authored keys plus the two git keys. |
6. Page Title & Header
| # | Description | Result | Comments |
|---|---|---|---|
| 6.1 | [page_title] is set to the [canonical_topic] of the ER frontmatter followed by “ - Quick Reference Sheet” (e.g., “Intervention - Quick Reference Sheet”). The [canonical_topic] is HTML-entity-encoded as needed (e.g., & for &) |
🟢 | Line 22: “Progesterone for Health & Longevity - Quick Reference Sheet”. |
| 6.2 | [header_topic] is set to the [canonical_topic] of the ER frontmatter, with HTML entities encoded as needed (e.g., & for &) |
🟢 | Line 417: “Progesterone for Health & Longevity”. |
| 6.3 | [header_subline_date] is set to [qrs_creation_date reformatted as MM/DD/YYYY] | 🟢 | Line 421: 08/04/2026, correctly derived from 2026-0804-0520. |
| 6.4 | [header_subline_model] is set to [qrs_creator_ai_fullname] | 🟢 | Line 425: Opus 5. |
| 6.5 | No additional header content appears: no badge, version stamp, AKA / alternate names line, source-AI attribution, audit date, or QRS variant marker. | 🟢 | Header contains only the title and the standard subline; the seven alternate names from ER line 30 are correctly omitted. |
7. At-A-Glance Section
| # | Description | Result | Comments |
|---|---|---|---|
| 7.1 | [at_a_glance] is dense, execution-oriented summary of the ER Conclusion section |
🟢 | Each clause maps to the ER Conclusion at lines 455–457: endometrial protection, cream failure, sleep and vasomotor, comparative safety, five-year horizon, sedation and bedtime dosing. |
| 7.2 | [at_a_glance] is no longer than 60 words | 🟢 | Exactly 60 words. |
| 7.3 | Every fact in [at_a_glance] is supported by a distinct passage in the ER. | 🟢 | Six clauses, six distinct ER Conclusion passages; no synthesis beyond the source. |
| 7.4 | It DOES NOT use acronyms or technical classifications that require specialist knowledge, uses plain-language terms instead | 🟢 | “uterine lining”, “skin creams”, “synthetic versions”, “drowsiness” — no acronyms, no clinical-register substitutions. |
| 7.5 | It DOES NOT cite specific trials (names, years, sample sizes, p-values) | 🟢 | “Trials support” is the only reference to trials; no names, years or sample sizes. |
| 7.6 | It DOES NOT cite effect sizes, relative risks, or statistical results | 🟢 | No numeric result of any kind; “five years” is a duration, not an effect estimate. |
8. Contraindications
| # | Description | Result | Comments |
|---|---|---|---|
| 8.1 | The section is derived from the ER Key Interactions & Contraindications section |
🟢 | All 12 items trace to ER lines 355–356. |
| 8.2 | [stop_items] represent the Contraindications from the ER | 🟢 | Seven absolute contraindications plus the five avoid-or-defer populations, complete and in ER order. |
| 8.3 | Individual [stop_items] are formatted as <li></li> | 🟢 | Twelve <li> elements at QRS lines 575–586. |
| 8.4 | Items are as concise as possible. No trailing explanations, no elaborations, no mechanistic rationale, no attributions, no citations, no study details. No content after an em-dash, en-dash, or hyphen-dash (e.g., “— dose reduction required”, “— reduced efficacy”) — these trailing clauses are stripped. Just the key fact. | 🟢 | Elaborations stripped: “including myocardial infarction and stroke”, “given the absence of an evidence base”, “where the tested population no longer applies”. No dash-trailing clauses remain. |
| 8.5 | Parenthetical qualifiers from the ER bullet — time windows, severity classes, threshold values, clinical staging — ARE preserved as part of the item, kept as concise as possible (shortened or trimmed where needed to fit the one-page budget, but never dropped entirely). | 🟢 | “(within 12 months)”, “(Child-Pugh Class C)”, “peanut allergy for peanut-oil capsules” and “more than 10 years past the final menstrual period” all preserved. |
| 8.6 | When the ER uses ranking notation inside parens (e.g., “>” for severity ordering) that depends on an explanatory phrase to interpret, normalize the items to a plain comma-separated list rather than carrying through the bare symbol. | N/A | The ER uses no ranking notation inside parentheses in its contraindication bullets. |
| 8.7 | If no [stop_items] are present the section is left empty | N/A | Twelve stop_items are present. |
9. Key Interactions
| # | Description | Result | Comments |
|---|---|---|---|
| 9.1 | The section is derived from the ER Key Interactions & Contraindications section |
🟢 | All eight items trace to ER lines 347–354. |
| 9.2 | [caution_items] represent the Key Interactions from the ER, excluding any that are already listed as Contraindications | 🟢 | All eight ER interaction bullets carried across; no overlap with the twelve stop_items. |
| 9.3 | Individual [caution_items] are formatted as <li></li> | 🟢 | Eight <li> elements at QRS lines 594–601. |
| 9.4 | Items are as concise as possible. No trailing explanations, no elaborations, no mechanistic rationale, no attributions, no citations, no study details. No content after an em-dash, en-dash, or hyphen-dash (e.g., “— dose reduction required”, “— reduced efficacy”) — these trailing clauses are stripped. Just the key fact. | 🟢 | Every “Caution;”/”Monitor;” rationale and every “Mitigation is…” clause stripped; the ER’s inline em-dash gloss on gabapentinoids is removed. |
| 9.5 | Parenthetical qualifiers from the ER bullet — example drug lists, time windows, severity classes, threshold values, clinical staging — ARE preserved as part of the item, kept as concise as possible (shortened or trimmed where needed to fit the one-page budget, but never dropped entirely). | 🟢 | Named drug lists retained for inducers, inhibitors, estrogens, sedative supplements, steroid-metabolism supplements and anticoagulants; the CNS-depressant parenthetical is trimmed to its drug classes, which is the permitted shortening rather than a drop. |
| 9.6 | When the ER uses ranking notation inside parens (e.g., “>” for severity ordering) that depends on an explanatory phrase to interpret, normalize the items to a plain comma-separated list rather than carrying through the bare symbol. | N/A | The ER uses no ranking notation inside parentheses in its interaction bullets. |
| 9.7 | If no [caution_items] are present the section is left empty | N/A | Eight caution_items are present. |
10. Protocol
| # | Description | Result | Comments |
|---|---|---|---|
| 10.1 | The section is derived from the ER Protocol section |
🟢 | Cells trace to ER “Therapeutic Protocol” lines 372, 373 and 375. |
| 10.2 | The three sets of [action] items cover the three most important actionable implementation aspects from the ER Protocol section |
🟢 | The evidence-leading endometrial-protection regimen, the monotherapy alternative, and the timing constraint that governs both — the three decision-critical items among the ER’s eleven protocol bullets. |
| 10.3 | If less that three distinct actionable implementation aspects are mentioned in the ER the unused sets are left empty and made invisible, not filled with placeholder text or empty-state phrasing. | N/A | The ER Therapeutic Protocol section contains eleven distinct actionable bullets. |
| 10.4 | All used [action_#label], [action#value], [action#_sub] items are filled with meaningful content derived from the ER Protocol section. |
🟢 | All nine spans populated; doses, cycle lengths and bleeding expectations all match ER lines 372–375. |
11. Time to Effect
| # | Description | Result | Comments |
|---|---|---|---|
| 11.1 | The three sets of [time] items cover the three most important time-to-effect aspects from the ER | 🟢 | Endometrial protection, vasomotor symptoms and sleep — three of the four aspects in ER line 402; bone at 6–12 months is correctly excluded as the Low-tier benefit. |
| 11.2 | The sets are picked and ordered by the magnitude of the related benefit | 🟢 | Endometrial protection (High tier) first, then hot flushes and night sweats and sleep (both Medium tier), in the ER’s own Medium-tier order. |
| 11.3 | If less that three distinct time-to-effect aspects are mentioned in the ER the unused sets are left empty and made invisible, not filled with placeholder text or empty-state phrasing. | N/A | The ER states four distinct time-to-effect aspects at line 402. |
| 11.4 | All used [time_#label], [time#value], [time#_sub] items are filled with meaningful content derived from the ER. | 🟢 | All nine spans populated; “first treated cycle”, “4–12 weeks” and “first night” match ER line 402, and the sub-lines match ER lines 170, 256 and 402. |
| 11.5 | If the ER does not provide any information on time to effect, the section is removed completely from the Protocol Panel |
N/A | The ER provides explicit time-to-effect data at line 402. |
12. Benefits
| # | Description | Result | Comments |
|---|---|---|---|
| 12.1 | The section is derived from the ER Expected Benefits section |
🟢 | All 13 items are ER Expected Benefits headings from lines 152–230. |
| 12.2 | Key variables are [benefits_high], [benefits_medium], [benefits_low], [benefits_speculative] | 🟢 | All four spans present and populated at QRS lines 544–565. |
| 12.3 | Items are as concise as possible. No explanations, no elaborations, no effect sizes, no qualifiers, no attributions, no citations, no study details, no mechanistic explanations, etc. Just the key fact. | 🟢 | Heading-level only; every Magnitude: paragraph and the “⚠️ Conflicted” markers are dropped. |
| 12.4 | Parenthetical content — including effect sizes, sample notes, mechanistic hints, and example studies — is stripped, NOT preserved. | 🟢 | No parentheses appear in any benefits span. |
| 12.5 | If no items of a specific sub-section (high, medium, low, speculative) are present the respective is set to “display=none”, not filled with “None documented in human trials to date” or similar empty-state phrasing. | N/A | All four ER benefit tiers are populated (1 High, 5 Medium, 4 Low, 3 Speculative). |
13. Risks
| # | Description | Result | Comments |
|---|---|---|---|
| 13.1 | The section is derived from the ER Potential Risks & Side Effects section |
🟢 | All 15 items are ER risk headings from lines 246–334. |
| 13.2 | Key variables are [risks_high], [risks_medium], [risks_low], [risks_speculative] | 🟢 | All four spans present and populated at QRS lines 613–640. |
| 13.3 | Items are as concise as possible. No explanations, no elaborations, no effect sizes, no qualifiers, no attributions, no citations, no study details, no mechanistic explanations, etc. Just the key fact. | 🟢 | Heading-level only; discontinuation rates, hazard ratios and the peanut-allergy prevalence figure are all dropped. |
| 13.4 | Parenthetical content — including frequencies, severity grades, sample notes, mechanistic hints, and example studies — is stripped, NOT preserved. | 🟢 | No parentheses appear in any risks span. |
| 13.5 | If no items of a specific sub-section (high, medium, low, speculative) are present the respective is set to “display=none”, not filled with “None documented in human trials to date” or similar empty-state phrasing. | N/A | All four ER risk tiers are populated (2 High, 6 Medium, 3 Low, 4 Speculative). |
14. Monitoring
| # | Description | Result | Comments |
|---|---|---|---|
| 14.1 | The section is derived from the ER Monitoring section |
🟢 | Rows trace to the ER biomarker table at lines 418–429. |
| 14.2 | All measurable/quantifiable biomarkers from the Monitoring section are listed |
🟢 | All ten ER biomarkers present, in ER order, with targets and rationales matching the ER’s Optimal Functional Range and Why Measure It columns. |
| 14.3 | [monitoring_cadence] is populated with the monitoring cadence/frequency derived from the ER Monitoring section. It is not left with placeholder text or empty. |
🟢 | QRS lines 770–774 condense ER line 431: 4-week symptom review, 3-month labs, 6–12 monthly thereafter, imaging and ultrasound rules, annual duration review. |
15. Qualitative Assessment
| # | Description | Result | Comments |
|---|---|---|---|
| 15.1 | The section is derived from the ER Monitoring section |
🟢 | Items trace to the ER qualitative marker list at lines 435–441. |
| 15.2 | All subjective/qualitative biomarkers from the Monitoring section are listed |
🟢 | All seven ER qualitative markers present, in ER order: sleep onset and wakings, next-morning alertness, vasomotor scoring, mood, bleeding pattern, breast tenderness and bloating, cognitive clarity and energy. |
Issues 04/08/2026 05:54
Pass rate 100.00%. No issues found.
Issues 04/08/2026 05:45
- 1.2 — Endometrial hedge dropped in At-A-Glance: [at_a_glance] (QRS lines 434–438) presents uterine-lining protection without qualification, while the ER Conclusion (ER line 455) attaches “though longer follow-up raises a question about whether it holds up over a decade” to the same claim.
- 2.8 — Full ER sentences carried into compact fields: [action_1_sub], [action_2_sub], [action_3_sub] (QRS lines 456–490) each run three sentences, [monitoring_cadence] (lines 774–779) reproduces four near-verbatim ER sentences, and [qualitative_item_1], [qualitative_item_2], [qualitative_item_4], [qualitative_item_6] (lines 788–803) retain the ER’s trailing explanatory clauses instead of being condensed.
Fixes 04/08/2026 05:45
- 1.2 — Endometrial hedge restored in At-A-Glance: [at_a_glance] now carries the ER Conclusion’s duration caveat as “Evidence beyond five years thins across the board”, so the uterine-lining claim is no longer presented unqualified; still 60 words.
- 2.8 — Protocol and time-to-effect subs condensed: [action_1_sub], [action_2_sub], [action_3_sub], [time_2_sub], and [time_3_sub] were cut from full ER sentences to compact single- or two-clause notes with no loss of fact.
- 2.8 — Monitoring cadence tightened: [monitoring_cadence] was reduced from four near-verbatim ER sentences to three short clauses covering the same 4-week, 3-month, 6–12-month, and annual-review schedule.
- 2.8 — Qualitative items stripped of trailing clauses: [qualitative_item_1], [qualitative_item_2], [qualitative_item_4], and [qualitative_item_6] lost the ER’s explanatory tails (e.g., “and warrant review if they do not”) while keeping the marker itself.
- 2.8 — Long marker rationale trimmed: [marker_6_why] and [marker_9_why] were shortened by removing the ER’s restated context (“Progesterone therapy has been shown to…”, “the problem cyclic dosing often addresses”).
Issues 04/08/2026 05:32
- 1.4 — Vaginal dosing under wrong action: [action_2_sub] (QRS 471–475) attaches vaginal dosing at 45–100 mg to “Symptom-directed monotherapy”, but the ER presents it exclusively as an off-label endometrial-protection route for those who “cannot tolerate oral sedation but need uterine cover” (ER 377).
- 7.4 — Specialist term in At-A-Glance: [at_a_glance] opens with “Body-identical progesterone” (QRS 434), a hormone-therapy term of art that a non-specialist would not use unprompted; the ER Conclusion itself avoids it in favour of “the version used in therapy is chemically identical to it” (ER 455).
Fixes 04/08/2026 05:32
- 1.4 — Vaginal dosing under wrong action: Removed the vaginal-dosing sentence from [action_2_sub], which the ER assigns to endometrial protection rather than symptom-directed monotherapy, and replaced it with the ER’s cyclic 300 mg for 14 days per cycle perimenopausal regimen.
- 7.4 — Specialist term in At-A-Glance: Replaced “Body-identical progesterone” with “Progesterone identical to the body’s own” and trimmed the third sentence to keep [at_a_glance] within the 60-word budget.
Issues 04/08/2026 05:25
- 1.3 — Bedtime claim broadened beyond oral: [action_3_value] reads “Bedtime, without exception” (QRS line 483), while the ER restricts the absolute statement to oral dosing (“Bedtime, without exception for oral dosing.”, ER line 375); the QRS therefore extends the claim to vaginal dosing, which the ER explicitly presents as the lower-sedation alternative.
Fixes 04/08/2026 05:25
- 1.3 — Bedtime claim scoped to oral dosing: Changed [action_3_value] from “Bedtime, without exception” to “Bedtime, without exception, for oral dosing”, restoring the route qualifier the ER attaches to the claim.