Sesame seed extract modestly lowers top-number blood pressure and cholesterol in short trials; whole-seed results are mixed. Some trials show lower glucose; a form of vitamin E rises. Sesame allergy can be severe; refined extracts are not proven protein-free. It can block a liver enzyme that clears several common drugs. Benefit is small; long-term disease and lifespan outcomes are unmeasured. (Full Review)
| Marker | Target | Why |
|---|---|---|
| Systolic / diastolic BP | 110–120 / 70–80 mmHg | Tracks the main extract signal |
| LDL-C | 50–80 mg/dL | Tracks the lipid signal |
| Total cholesterol | 160–200 mg/dL | Companion to LDL |
| HDL-C | >60 mg/dL | Sesamin effect is inconsistent |
| Triglycerides | <80–100 mg/dL | Little extract signal; still cardiometabolic |
| Fasting glucose | 75–90 mg/dL | Sesame-product glucose signal |
| HbA1c | 4.8–5.3% | 8–12 week glucose average |
| hs-CRP | <0.7 mg/L | Inflammation context |
| Gamma-tocopherol | No established target; track rise from own baseline | Confirms CYP4F2 engagement |
| ALT / AST | ALT <25–30 U/L | Safety with polypharmacy |
| INR (if on warfarin) | Stay in the individual’s prescribed band | CYP2C9 interaction |
Cadence: 4–8 weeks, then every 3–6 months if continued; INR 3–7 days after starting or stopping if on warfarin